Research in “Cancer Genetics Lab”  is focused on Genetic, Epigenetic and Expression level studies of genes involved in Breast Cancer, Pancreatic Cancer and Head & Neck Cancer. Next generation sequencing studies to understand deregulated pathways implicated in these cancers and are also being investigated in Pakistani population. 

1.      Tareen MU, Riaz S, Malik SS, Zahid S, Khursheed A, Tariq F, Abbas F, Malik MN, Anis RA, Anees M, Murtaza I, Sultan A. CYP2C19*17 association with higher plasma 4-hydroxy tamoxifen in Pakistani (estrogen-positive) breast cancer patients. Experimental Biology and Medicine (Maywood). 2023:15353702231187640. doi: 10.1177/15353702231187640. Epub 2023 Sep 9.

2.      Ishtiaq A, Nasrullah MA, Khan JS, Malik S, Tareen U, Anees M, Sultan A, Murtaza I. A cohort study investigating the role of Bisphenol A in the molecular pathogenesis of breast cancer. Journal of Cancer Research and Clinical Oncology 2023;149(16):14565-14575. doi: 10.1007/s00432-023-05247-3. Epub 2023.

3.      Rehan T, Tahir A, Sultan A, Alabbosh KF, Waseem S, Ul-Islam M, Khan KA, Ibrahim EH, Ullah MW, Shah N. Mitigation of Benzene-Induced Haematotoxicity in Sprague Dawley Rats through Plant-Extract-Loaded Silica Nanobeads. Toxics. 2023;11(10):865. doi: 10.3390/toxics11100865.

4.      Sarwar S, Tanveer R, Mulla M, Mulla M, Sabir M, Sultan A, Malik SA. Human papillomavirus, tobacco, and poor oral hygiene can act synergetically, modulate the expression of the nuclear factor kappa B signaling pathway for the development and progression of head and neck cancer in the Pakistani population. Chinese Medical Journal. 135(15):1829-1836. 2022 Aug 5. doi: 10.1097/CM9.0000000000001970.

5.      Bukhari S, Siddique MH, Naeem A, Khan I, Ali Z, Essa A, Fazal F, Anis RA, Moran L, Sultan A, Murtaza I, Vanhara P, Anees M. Combined efficacy of Cinnamomum zeylanicum and doxorubicin against leukemia through regulation of TRAIL and NF-kappa B pathways in rat model. Molecular Biology Reports. 49(7):6495-6507. 2022 May 17. doi: 10.1007/s11033-022-07478-y.

6.      Sarwar S, Tareen MU, Sabir M, Sultan A, Malik SA. NF-κB1 intronic region polymorphisms as risk factor for head and neck cancer in HPV-infected population from Pakistan. Current Molecular Medicine. 22(1):74-82. 2022. doi: 10.2174/1566524021666210302144344.

7.      Ishtiaq A, Ali T, Bakhtiar A, Bibi R, Bibi K, Mushtaq I, Li S, Khan W, Khan U, Anis RA, Anees M, Sultan A, Murtaza I. Melatonin abated Bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling. Environmental Science and Pollution Research. 2021 Apr;28(14):17789-17801. doi: 10.1007/s11356-020-12129-5.

8.      Ishtiaq A, Bakhtiar A, Silas E, Saeed J, Ajmal S, Mushtaq I, Ali T, Wahedi HM, Khan W, Khan U, Anees M, Sultan A, Murtaza I. Pistacia integerrima alleviated Bisphenol A induced toxicity through Ubc13/p53 signalling. Molecular Biology Reports. 2020 Aug 8. 

9.      Rehan T, MacEwan D, Shah N, Rehan T, Tahira R, Murad S, Anees M, Murtaza I, Farman M, Sultan A. Apoptosis of Leukemia Cells by Ocimum basilicum Fractions Following TNF alpha Induced Activation of JNK and Caspase 3. Current Pharmaceutical Design. Oct 2019.

10.  Khan AHA, Ayaz M, Arshad M, Yousaf S, Khan MA, Anees M, Sultan A, Nawaz I, Iqbal M. Biogeochemical Cycle, Occurrence and Biological Treatments of Polycyclic Aromatic Hydrocarbons (PAHs). Iranian Journal of Science and Technology Transaction A-Science. June 2019; 43 (A3): 1393-1410  

11.  Riaz S, Din SM, Tareen MU, Tariq F, Latif Y, Siddiqi S, Sultan A, Mansoor A. Genetic Polymorphism of CYP2C19 in Pakistani Population. Iranian Journal of Pharmaceutical Research. April 2019; 18(2): 1097-1102. 

12.  Riaz S, Mansoor A, Siddiqi S, Tareen MU, Rubab S, Batool A, Anwarullah, Sultan A. Association of CYP2C19*2 and *17 genetic variants with hypertension in Pakistani population. Tropical Journal of Pharmaceutical Research. April 2019; 18 (4): 851-855

13.  Akram Z, Ahmed P, Kajigaya S, Satti TM, Satti HS, Chaudhary QUN, Gutierrez-Rodrigues F, Ibanez PF, Feng X, Mahmood SK, Ghafoor T, Shahbaz N, Khan MA, Sultan A. Epidemiological, clinical and genetic characterization of aplastic anemia patients in Pakistan. Annals of Hematology. Feb 2019;98(2):301-312. doi: 10.1007/s00277-018-3542-z.

14.  Jan MI, Khan RA, Sultan A, Ullah A, Ishtiaq A, Murtaza I. Analysis of NT-proBNP and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease. Pakistan Journal of Medical Sciences. Jan-Feb 2019;35(1):183-188. doi: 10.12669/pjms.35.1.148

15.  Ali T, Mushtaq I, Maryam S, Farhan A, Saba K, Jan MI, Sultan A, Anees M, Duygu B, Hamera S, Tabassum S, Javed Q, da Costa Martins PA, Murtaza I. Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs. Archives of Biochemistry and Biophysics. 2019; 661:56-65. doi: 10.1016/j.abb.2018.11.007.

16.  Rehan T, Tahira R, Ullah H, Tareen U, Rehan T, Anees M, Murtaza I and Sultan A. In vitro bioactivities and subacute toxicity study of O. basilicum, T. vulgaris and R. officinalis. Turkish Journal of Biochemistry. 2018 Aug. 43 (4): 447-455 DOI: https://doi.org/10.1515/tjb-2017-0267

17.  Jan MI, Khan RA, Malik A, Ali T, Bilal M, Bo L, Sajid A, Urehman N, Waseem N, Nawab J, Ali M, Majeed A, Ahmad H, Aslam S, Hamera S, Sultan A, Aneesa M, Javed Q and Murtaza I. Data of expression status of miR- 29a and its putative target mitochondrial apoptosis regulatory gene DRP1 upon miR-15a and miR-214 inhibition. Data in Brief. 2017 Dec. 20(16):1000-1004.             doi: 10.1016/j.dib.2017.12.040.

18.  Anwarullah, Sultan A, Usmani MA, Ghaffar M, Ali J, Badshah M, Ahmad N. Absence of SNCA polymorphisms in Pakistani Parkinsons disease patients.  JPMA. Journal of the Pakistan Medical Association. 2017 Oct; 67(10):1512-1516.

19.  Jan MI, RA Khan, T Ali, MBilal, L Bo, A Sajid, A Malik, N Urehman, N Waseem, J Nawab, M Ali, A Majeed, H Ahmad, S Aslam, S Hamera, A Sultan, M Anees, Q Javed , I Murtaza. Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. Archives of Biochemistry and Biophysics. Online 6 September 2017. doi.org/10.1016/j.abb.2017.09.001.

20.  Anwarullah A, Paramasivam N, Abbasi R, Khan K, Sultan A, Schlesner M, von Engelhardt J, Ahmad N, Aslam M. A report of whole-genome sequencing in neurologic Wilson’s disease. Neurology India. 2017 May-Jun;65(3):629-631.

21.  Anwarullah A, Aslam M, Badshah M, Abbasi R, Sultan A, Khan K, Ahmad N, Engelhardt JV. Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson’s disease: a case control study. Genes and Environment. 2017 Jul 1;39:18. doi: 10.1186/s41021-017-0078-8.

22.  Aqib Hassan Ali Khan, Sundus Tanveer, Shagufta Alia, Mariam Anees, Aneesa Sultan, Mazhar Iqbal, Sohail Yousaf. Role of nutrients in bacterial biosurfactant production and effect of biosurfactant production on petroleum hydrocarbon biodegradation. Ecological Engineering 104 (2017) 158–164

23.  Obaid-ur-Rahman  Abid, Muhammad Ayaz,  Wajid Rehman,  Kamran Mehdi,  Arif Ali, Abdul Wadood,  Fazal Rahim, Aneesa Sultan,  Mehreen Ghufran, Sadullah Mir, Muhammad Tauseef Qureshi. Synthesis, Enzyme Inhibition, and Molecular Docking Studies of Hydrazones from Dichlorophenylacetic Acids. Journal of the Chinese Chemical Society. 63 (12):1015-1021. 2016 Dec. DOI: 10.1002/jccs.201600163

24.  Sajid Mansoor, Sana Riaz, Sara Kausar, Sadia Muhammad Din, Aneela Javed, Aneesa Sultan, Atika Mansoor. Can IFNL3 polymorphisms predict response to interferon/ribavirin treatment in hepatitis C patients with genotype 3? Journal of General Virology. 2016 Oct;97(10):2592-2598

25.  Muhammad Nawaz, Farah Fatima, Irina Nazarenko, Karin Ekström, Iram Murtaza, Mariam Anees, Aneesa Sultan, Luciano Neder, Giovanni Camussi, Hadi Valadi, Jeremy A. Squire & Thomas Kislinger. Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery. Expert Review of Proteomics. 2016;13(4):395-409.

26.  Afzal M, M Amir, M J Hassan, S Murad, I Murtaza, M Anees and A Sultan. Clinical Role of HER2 gene Amplification and chromosome 17: Study on 154 IHC-Equivocal Cases of Invasive Breast Carcinoma Patients. Tumor Biology. 2016 Jan 6.: 37(7):8665-72.

27.  Murad S, A Anwar, ZZ Piracha, A Sultan. LRIG1 expression during homeostasis and skin wound healing in mice Journal of Biological Regulators and Homeostatic Agents. 2015 Oct-Dec;29(4):829-33.

28.  Ahmed I, M Sajed, A Sultan, I Murtaza, S Yousaf, B Maqsood, P Vanhara, M Anees. The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections. EXCLI Journal. 2015 Aug 4;14:916-25.

29.  Summer G, S Murad, N Ehsan, P Bloodsworth, A Sultan and M Faheem. “Transcriptional up-regulation of BMP-4 and BMPR-II genes in the peripheral blood of breast cancer patients: A pilot study.” Cancer Biomarkers. 2015 ;15(5):551-7

30.  Anees M, R A Anis, S Yousaf, I Murtaza, A Sultan, M Arslan, M Shahab. Effect of maternal iodine supplementation on thyroid function and birth outcome in goiter endemic areas. Current Medical Research and Opinion. 2015 Apr;31(4):667-74.

31.  Noreen M, S Murad, M Furqan, A Sultan, P Bloodsworth. Knowledge and Awareness about Breast Cancer and its Early Symptoms among Medical and Non-Medical Students of Southern Punjab, Pakistan. Asian Pacific Journal of Cancer Prevention. 2015;16(3):979-84.

32.  Spaderna S, O Schmalhofer, M Wahlbuhl, A Dimmler, K Bauer, A Sultan, F Hlubek, A Jung, D Strand, A Eger, T Kirchner, J Behrens, T Brabletz. The EMT inducer ZEB1 promotes metastasis and a loss of cell polarity in cancer. Cancer Research. 2008 Jan 15;68(2):537-44.

33.  Aigner K, B Dampier, L Descovich, M Mikula, A Sultan, M Schreiber, W Mikulits, T Brabletz, D Strand, P Obrist, W Sommergruber, N Schweifer, A Wernitznig, H Beug, R Foisner and A Eger. The transcription factor ZEB1 (δEF1) induces tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene. 2007 Oct 25;26(49):6979-88.

34.  Aigner K, L Descovich, M Mikula, A Sultan, B Dampier, S Bonne, M Schreiber, FV Roy, W Mikulits, T Brabletz, H Beug, R Foisner and A Eger. The transcription factor ZEB1 (δEF1) represses Plakophilin 3 during human cancer progression. 2007. FEBS Letters. 2007 Apr 17;581(8):1617-24. 

35.  Zafar M, Y Mussaddeq, S Akhter and A Sultan. Weight-length and condition factor relationship of thaila, Catla catla from Rawal dam Islamabad, Pakistan. 2003. Pakistan Journal of Biological Sciences 6(17): 1532-1534. 

1.    Saeed T, Ahmad N, Zubair S, Sultan A, Abbasi R. 2023. A Pharmacological Network Based Approach to Identify Chemotherapeutics and Natural Compliments Targets. Shaukat Khanum Cancer Symposium. November 3-5, 2023. Serena Hotel, Peshawar Pakistan.

2.      Aneesa Sultan*, Muhammad Afzal, Anum Khursheed and Mohammed Amir. 2017. HER2 Gene Amplification & Chromosome 17 aneusomy in IHC Equivocal Cases. EMBL Conference, Cancer Genomics. November 5 - 8 2017. Heidelberg, Germany.

3.      Touseef Rehan, Mariam Anees and Aneesa Sultan*. 2015. Screening  of  Rosemarinus officinalis, Thymus vulgaris and Scabiosa candollie for subacute toxicity in male albino Rats of Sprague Daweley strain. 7^th Chemistry Conference 2015 on “Chemistry in Engineering and Life Sciences”. November 24-26, 2015. PINSTECH.

4.      Ali I, A Sultan. 2013. Investigation of ZEB1/Delta‐EF1 Gene Expression in Breast Cancer Tissue of Pakistani Women. International Conference on the Applications of Molecular Biology in Medicine and Agriculture. August 20‐22, 2013. Quaid-i-Azam University, Islamabad. 

5.      Rehan T, A Sultan, U Malik, A Zahra, M Khan, S A Malik, A A Khan. 2013. Epigenetic Analysis of Embryonic Stem Cells Specific Genes in Blood of Normal and Leukemic Patients. International Conference on the Applications of Molecular Biology in Medicine and Agriculture. August 20‐22, 2013. Quaid-i-Azam University, Islamabad.

6.      Sultan A, K. Aigner, L. Descovich, H. Beug, R. Foisner and A. Eger . 2007. The Transcription Factor ZEB1 (δEF1) Promotes Tumor Cell Dedifferentiation by Repressing Master Regulators of Epithelial Polarity. 32nd FEBS Congress, Molecular Machines, July 7-12, 2007 Vienna, Austria.

7.      Azeemi N Z and A Sultan. Characterization of Bioinformatics Applications on Multimedia Processor, in Proc. Proceedings Cairo International Biomedical Engineering Conference 2006, Cairo, Egypt, December, 2006.

8.      Azeemi N Z, A Sultan and A. Muhammad. Parameterized Characterization of Bioinfomatics Workload on SIMD Architecture, in Proc. 2006 International Conference on Information and Automation, pages 189 - 194, Colombo, Sri Lanka, December, 2006.

9.      Sultan A, Fazle-Subhan, F Tahir, M Qayyum, A Khanum and A Dil. 2001. Serum Alpha Feto-Protein(AFP) and Beta Human Chorionic Gonadotropin (ß-hCG) levels as tumor markers. 21st Pakistan Congress of Zoology held at University of Agriculture Faisalabad Pakistan. 15-17. March, 2001.

• Role of CYP Genotypes in Drug Response among Pakistani Breast Cancer patients
• Whole exome and transcriptome studies of pathways/genes deregulated in Pancreatic Cancer, Head & Neck Cancer and Breast Cancer