Back
 
Name: Dr. Muhammad Ansar
Designation: Professor
Department: Biochemistry (BMB)


Qualifications: PhD     2004    Department of Biological Sciences
                        Quaid-I-Azam University,
                        Islamabad, Pakistan
MSc    2000      Department of Biological Sciences
                        Quaid-I-Azam University,
                        Islamabad, Pakistan


Phone: +92-51 9064-3146
Email: ansar@qau.edu.pk
Status: On Job
Other Weblink:

View Resume

Research Interests Publications Conferences Research Projects

My research group is mainly involved in the identification and characterization of genes responsible for retinal and neurological disorders. We are currently using commercially available SNP microarray platforms for the genetic analysis of large families with retinal and neurological disorders. Our pilot work on these disorders revealed the role of methylation and glycosylation in the human nerurodevelopmental disorders. However exploration of additional players involved in multi component complexes involved in methylation and glycosylation will enable us to understand neurodevelopment processes in a better way. These players will be identified through genetic analysis of additional families and integration of data from expression studies and protein interaction maps. Additionally our group is also working on large scale genomic analysis, expression studies related to cancers and copy number analysis.

1.  Khan S, Habib R, Mir H, Umm-E-Kalsoom, Naz G, Ayub M, Shafique S, Yamin T, Ali N, Basit S, Wasif N, Kamran-Ul-Hassan Naqvi S, Ali G, Wali A, Ansar M, Ahmad W. Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan. Clin Exp Dermatol. 2011 Aug;36(6):652-4.

2.  Rafiq MA, Kuss AW, Puettmann L, Noor A, Ramiah A, Ali G, Hu H, Kerio NA, Xiang Y, Garshasbi M, Khan MA, Ishak GE, Weksberg R, Ullmann R, Tzschach A, Kahrizi K, Mahmood K, Naeem F, Ayub M, Moremen KW, Vincent JB, Ropers HH, Ansar M, Najmabadi H. Mutations in the Alpha 1,2-Mannosidase Gene, MAN1B1, Cause Autosomal-Recessive Intellectual Disability. Am J Hum Genet. 2011 Jul 15;89(1):176-82.

3.   Ali G, Lee K, Andrade PB, Basit S, Santos-Cortez RL, Chen L, Jelani M, Ansar M, Ahmad W, Leal SM. Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3. Hum Hered. 2011;71(2):106-12.

4.  Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O’Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK. Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways. Cell. 2011 May 13;145(4):513-28.

5.      Basit S, Iqbal Z, Umicevic-Mirkov M, Kamran Ul-Hassan Naqvi S, Coenen M, Ansar M, van Bokhoven H, Ahmad W. A novel deletion mutation in proteoglycan-4 underlies camptodactyly-arthropathy-coxa-vara-pericarditis syndrome in a consanguineous pakistani family. Arch Med Res. 2011 Feb;42(2):110-4.

6.   Khan MA, Rafiq MA, Noor A, Ali N, Ali G, Vincent JB, Ansar M. A novel deletion mutation in the TUSC3 gene in a consanguineous Pakistani family with autosomal recessive nonsyndromic intellectual disability. BMC Med Genet. 2011 Apr 22;12(1):56.

7.      Wasif N, Naqvi SK, Basit S, Ali N, Ansar M, Ahmad W. Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families. Hum Genet. 2011 129(4):419-424.

8.   Basit S, Lee K, Habib R, Chen L, Umm-E-Kalsoom, Santos-Cortez RL, Azeem Z, Andrade P, Ansar M, Ahmad W, Leal SM. DFNB89, a novel autosomal recessive nonsyndromic hearing impairment locus on chromosome 16q21-q23.2. Hum Genet. 2011 129(4):379-385.

9.  Borck G, Rehman AU, Lee K, Pogoda HM, Kakar N, von Ameln S, Grillet N, Hildebrand MS, Ahmed ZM, Nürnberg G, Ansar M, Basit S, Javed Q, Morell RJ, Nasreen N, Shearer AE, Ahmad A, Kahrizi K, Shaikh RS, Ali RA, Khan SN, Goebel I, Meyer NC, Kimberling WJ, Webster JA, Stephan DA, Schiller MR, Bahlo M, Najmabadi H, Gillespie PG, Nürnberg P, Wollnik B, Riazuddin S, Smith RJ, Ahmad W, Müller U, Hammerschmidt M, Friedman TB, Riazuddin S, Leal SM, Ahmad J, Kubisch C. Loss-of-Function Mutations of ILDR1 Cause Autosomal-Recessive Hearing Impairment DFNB42. Am J Hum Genet. 2011 Feb 11;88(2):127-37.

10.  Ahmed ZM, Yousaf R, Lee BC, Khan SN, Lee S, Lee K, Husnain T, Rehman AU, Bonneux S, Ansar M, Ahmad W, Leal SM, Gladyshev VN, Belyantseva IA, Van Camp G, Riazuddin S, Friedman TB, Riazuddin S. Functional Null Mutations of MSRB3 Encoding Methionine Sulfoxide Reductase Are Associated with Human Deafness DFNB74. Am J Hum Genet 2011 7;88(1):19-29.

  1. Nicholas AK, Khurshid M, Désir J, Carvalho OP, Cox JJ, Thornton G, Kausar R, Ansar M, Ahmad W, Verloes A, Passemard S, Misson JP, Lindsay S, Gergely F, Dobyns WB, Roberts E, Abramowicz M, Woods CG. WDR62 is associated with the spindle pole and is mutated in human microcephaly. Nature Genetics 2010 Nov; 42 (11):1010-4.

  2. Rafiq MA, Ansar M, Marshall CR, Noor A, Shaheen N, Mowjoodi A, Khan MA, Ali G, Amin-Ud-Din M, Feuk L, Vincent JB, Scherer SW. Mapping of three novel loci for non-syndromic autosomal recessive mental retardation (NS-ARMR) in consanguineous families from Pakistan. Clinical Genetics 2010; 78(5): 478-483.

  3. Kousar R, Nawaz H, Khurshid M, Ali G, Khan SU, Mir H, Ayub M, Wali A, Ali N, Jelani M, Basit S, Ahmad W, Ansar M. Mutation Analysis of the ASPM Gene in 18 Pakistani Families With Autosomal Recessive Primary Microcephaly. Journal of Child Neurology 2010; 25(6) 715-720.

14. Basit S, Ali G, Wasif N, Ansar M, Ahmad W. Genetic mapping of a novel hypotrichosis locus to chromosome 7p21.3-p22.3 in a Pakistani family and screening of the candidate genes.  Hum Genet 2010 Aug;128(2):213-20.

15. Schraders M, Lee K, Oostrik J, Huygen PL, Ali G, Hoefsloot LH, Veltman JA, Cremers FP, Basit S, Ansar M, Cremers CW, Kunst HP, Ahmad W, Admiraal RJ, Leal SM, Kremer H.  Homozygosity Mapping Reveals Mutations of GRXCR1 as a Cause of Autosomal-Recessive Nonsyndromic Hearing Impairment. Am J Hum Genet. 2010 86(2):138-147.

16.  Kalsoom UE, Habib R, Khan B, Ali G, Ali N, Ansar M, Ahmad W. Mutations in lipase H gene underlie autosomal recessive hypotrichosis in five Pakistani families. Acta Derm Venereol. 2010;90(1):93-94.

17.  Azeem Z, Naqvi SK, Ansar M, Wali A, Naveed AK, Ali G, Hassan MJ, Tariq M, Basit S, Ahmad W. Recurrent mutations in functionally-related EDA and EDAR genes underlie X-linked isolated hypodontia and autosomal recessive hypohidrotic ectodermal dysplasia. Archives of Dermatology Research. 2009 Sep; 301(8):625-629.

18.  Schultz JM, Khan SN, Ahmed ZM, Riazuddin S, Waryah AM, Chhatre D, Starost MF, Ploplis B, Buckley S, Velásquez D, Kabra M, Lee K, Hassan MJ, Ali G, Ansar M, Ghosh M, Wilcox ER, Ahmad W, Merlino G, Leal SM, Riazuddin S, Friedman TB, Morell RJ. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. American Journal of Human Genetics. 2009 Jul; 85(1):25-39.

19.  Chishti MS, Lee K, McDonald ML, Hassan MJ, Ansar M, Ahmad W, Leal SM. Novel autosomal recessive non-syndromic hearing impairment locus (DFNB71) maps to chromosome 8p22-21.3. Journal of Human Genetics (2009) Mar 54 (3): 141-144.

20.  Naz G, Khan B, Ali G, Azeem Z, Wali A, Ansar M, Ahmad W. Novel missense mutations in lipase H (LIPH) gene causing autosomal recessive hypotrichosis (LAH2). Journal of Dermatological Science 54 (2009) 12–16.

21. Basit S, Naqvi SK, Wasif N, Ali G, Ansar M, Ahmad W. A novel insertion mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene underlies Grebe-type chondrodysplasia in a consanguineous Pakistani family. BMC Med Genet. 2008 Nov 27; 9:102.

22. Attya Bhatti, Lee K, McDonald ML, Hassan MJ, Gutala R, Muhammad Ansar, Wasim Ahmad, Leal SM. Mapping of a new autosomal recessive non-syndromic hearing impairment locus (DFNB45) to chromosome 1q43-q44. Clin Genet. 2008 Apr 73 (4): 395-398.

23.  Hassan MJ, Mahmood S, Ali G, Bibi N, Waheed I, Rafiq MA, Muhammad Ansar, Wasim Ahmad. Intragenic deletions in the dystrophin gene in 211 Pakistani Duchenne muscular dystrophy patients. Pediatr Int. 2008 Apr 50(2):162-166.

24. Collin RW, Kalay E, Tariq M, Peters T, van der Zwaag B, Venselaar H, Oostrik J, Lee K, Ahmed ZM, Caylan R, Li Y, Spierenburg HA, Eyupoglu E, Heister A, Riazuddin S, Bahat E, Ansar M, Arslan S, Wollnik B, Brunner HG, Cremers CW, Karaguzel A, Ahmad W, Cremers FP, Vriend G, Friedman TB, Riazuddin S, Leal SM, Kremer H. Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal-recessive nonsyndromic hearing impairment DFNB35. American Journal of Human Genetics. 2008 Jan 82(1):125-138.

25. Peter John, Muhammad Tariq, Muhammad Arshad Rafiq, Muhammad Amin-Ud-Din, Dost Muhammad, Ishrat Waheed, Muhammad Ansar, Wasim Ahmad. Recurrent intragenic deletion mutation in desmoglein 4 gene underlies autosomal recessive hypotrichosis in two Pakistani families of Balochi and Sindhi origins. Archives of Dermatology Research 2006; 298(3):135-137.

26.  Abdul Wali, Muhammad Ansar, Muhammad Nasim Khan, W Ahmad. Atrichia with papular lesions resulting from a novel insertion mutation in the human hairless gene. Clinical Experimental Dermatology 2006; 31(5):695-698.

27. Sajid Malik, Amir Ali Abbasi, Muhammad Ansar, Wasim Ahmad, MC Koch, KH Grzeschik. Genetic Heterogeneity of synpolydactyly: a novel locus SPD3 maps to chromosome 14q11.2-q12. Clinical Genetics 2006; 69(6):518-524.

28.  Asma Gul, Muhammad Jawad Hassan, Saqib Mahmood, Wenje C, Safa R, Muhammad Imran Naseer, Lisa D, Noor Muhammad, Muhammad Arshad Rafiq, Muhammad Ansar, Muhammad Salman Chishti, Ghazanfar Ali, Teepu Siddique, Wasim Ahmad. Genetic studies of autosomal recessive primary microcephaly in 33 Pakistani families: novel sequence variants in ASPM gene. Neurogenetics 2006; 7 (2): 105-110.

29.  Muhammad Jawad Hassan, Santos RL, Muhammad Arshad Rafiq, Chahrour MH, Pham TL, Muhammad Wajid, Hijab N, Wambangco M, Lee K, Muhammad Ansar, Yan K, Wasim Ahmad, Leal SM. A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3. Human Genetics 2006; 118:605–610.

30. Santos RL, Muhammad Wajid, Muhammad Nasim Khan, McArthur N, Pham TL, Bhatti A, Lee K, Saba Irshad, Asif Mir, Yan K, Chahrour MH, Muhammad Ansar, Ahmad W, Leal SM. Novel sequence variants in the TMC1 gene in Pakistani families with autosomal recessive hearing impairment. Human Mutation 2005; 26:396.

31.  Muhammad Aslam, Muhammad Wajid, Maria H. Chahrour, Muhammad Ansar, Sayedul Haque, Thanh L. Pham, Regie P. Santos, Kai Yan, Wasim Ahmad, Suzanne M. Leal. A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3. American Journal of Medical Genetics 2005; 133A, 18 – 22.

32. Asif Mir, Muhammad Ansar, Maria H. Chahrour, Thanh L. Pham, Muhammad Wajid, Sayedul Haque, Kai Yan, Wasim Ahmad, Suzanne M. Leal. Mapping of a novel autosomal recessive nonsyndromic deafness locus (DFNB46) to chromosome 18p11.32-p11.31. American Journal of Medical Genetics 2005; 133A, 23 – 26.

33.  Muhammad Ansar, Maria Chahrour, Muhammad Amin Ud Din, Muhammad Arshad, Sayed-ul-Haque, Thanh L Pham, Kai Yan, Wasim Ahmad, Suzanne M Leal. DFNB44, a Novel Autosomal Recessive Non-Syndromic Hearing Impairment Locus, Maps to Chromosome 7p14.1-q11.22. Human Heredity. 2004; 57:195-199.

34.  Muhammad Arshad Rafiq, Muhammad Ansar, Saqib Mahmood, Sayedul Haque, Muhammad Faiyaz ul Haque, Suzanne M Leal, Wasim Ahmad. A recurrent intragenic deletion mutation in DSG4 gene in three Pakistani families with autosomal recessive hypotrichosis. Journal of Investigative Dermatology (2004) 123: 247 - 248.

35.  Muhammad Arshad Rafiq, Muhammad Ansar, Thanh L Pham, Mohammad Amin-ud-Din, Maqsood Anwar, Sayedul Haque, Maria Chahrour, Kai Yan, Suzanne M. Leal, Wasim Ahmad. Localization of a novel locus for hereditary nail dysplasia to chromosome 17q25.1-17q25.3. Clinical Genetics (2004) 66: 73 - 78.

36.  Muhammad Ansar, Mohammad Amin-ud-Din, Muhammad Arshad, Muhammad Sohail, Mohammad Faiyaz ul Haque, Sayedul Haque, Wasim Ahmad, Suzanne M. Leal. A novel autosomal recessive non-syndromic deafness locus (DFNB35) maps to14q24.1-14q24.3 in large consanguineous kindred from Pakistan. European Journal of Human Genetics (2003) 11: 77 - 80.

37.  Muhammad Ansar, Mohammad Ramzan, Thanh L. Pham, Kai Yan, Syed Muhammad Jamal, Sayedul Haque, Wasim Ahmad, Suzanne M. Leal. Localization of A Novel Autosomal Recessive Non-Syndromic Hearing Impairment Locus (DFNB38) to 6q26-q27 in a Consanguineous Kindred from Pakistan. Human Heredity (2003) 55: 71 –74.

38.  Muhammad Arshad Rafique, Muhammad Ansar, Syed Muhammad Jamal, Muhammad Sohail, Mohammad Faiyaz-Ul-Haque, Sayedul Haque, Suzanne M. Leal, Wasim Ahmad. A Locus for Hereditary hypotrichosis localized to Human Chromosome 18q21.1. European Journal of Human Genetics (2003) 11: 623 - 628.

39.  Muhammad Wajid, Amir Ali Abbasi, Muhammad Ansar, Thanh L. Pham, Kai Yan, Sayedul Haque, Wasim Ahmad, Suzanne M. Leal. DFNB39, a recessive form of sensorineural hearing impairment, maps to chromosome 7q11.22-q21.12. European Journal of Human Genetics (2003) 11: 812–815.

Quaid-i-Azam University Islamabad, 45320, Pakistan.
Tel: +92-51 9064 0000, Email:webmaster@qau.edu.pk